TB-500

Thymosin Beta-4 analogue. Systemic healing and tissue regeneration for whole-body recovery.

Last updated: May 2026

What is TB-500?

TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4 (Tβ4), a protein found in all human cells at particularly high concentrations in platelets and wound fluid. It plays a critical role in cell migration, angiogenesis, and the inflammatory response following injury. Browse the full peptide library for related healing compounds.

Unlike BPC-157 which works more locally around the injection site, TB-500 is a systemic healing peptide that travels throughout the body via the bloodstream, making it effective even when injected far from the injury. This makes it uniquely suited for multiple injuries, widespread inflammation, or systemic recovery needs.

Athletes have used TB-500 extensively for accelerating recovery from muscle tears, tendon injuries, and chronic overuse injuries. For skin-specific healing, consider combining with GHK-Cu. For gut inflammation alongside systemic healing, KPV can be run concurrently. TB-500 is also studied for cardiac repair, wound healing, and has generated interest for its potential hair regrowth effects.

How It Works

Actin Regulation: TB-500's primary mechanism is binding to actin (G-actin), a protein critical to cell structure and movement. This promotes cell migration to injury sites: the first step in healing.

Angiogenesis: Like BPC-157, TB-500 promotes the formation of new blood vessels, improving delivery of oxygen and nutrients to damaged tissue.

Anti-Inflammatory: TB-500 modulates inflammation by downregulating inflammatory cytokines and promoting an anti-inflammatory environment at injury sites.

Stem Cell Activation: TB-500 activates progenitor cells (stem-cell-like cells) that differentiate into muscle, nerve, and connective tissue, enabling true tissue regeneration rather than just scar formation.

Benefits

Systemic healing: reaches all tissues via bloodstream
Accelerated muscle, tendon, and ligament repair
Reduced inflammation throughout the body
Improved flexibility and range of motion
Cardiac tissue repair (studied in heart failure models)
Potential hair regrowth in androgenic alopecia
Nerve repair and neuroprotection

Dosing Protocol

Phase	Dose	Frequency	Duration
Loading Phase	5–10mg	2x per week	Weeks 1–4
Maintenance	2.5–5mg	Once weekly	Weeks 5–12
Injury Protocol	5mg	2x per week	4–6 weeks

Always start at the lowest effective dose and titrate up gradually.

Side Effects

Common

⚠Fatigue or lethargy (common in first 1–2 weeks, resolves)
⚠Mild headache
⚠Injection site reactions
⚠Temporary head rush or lightheadedness

Rare

•Tumor growth promotion (theoretical concern: avoid with active cancer)
•Flushing
•Nausea at high doses

Who Should NOT Use TB-500

✕Active cancer or history of cancer
✕Pregnancy or breastfeeding
✕Lyme disease (anecdotal concern about symptom exacerbation)

What to Expect

Week 1–2

Some users feel fatigue as the immune and inflammatory systems respond. Acute inflammation at injury sites may temporarily increase then resolve.

Week 2–4

Noticeable improvement in pain and mobility. Stiffness reduces. Many report injuries healing faster than any previous protocol.

Week 4–8

Significant tissue repair. Users typically transition to maintenance dosing. Energy and performance improve as systemic inflammation drops.

Month 3+

Most complete their cycle. Hair regrowth users may start to notice early effects around month 3.

Notes from Ho Chi Minh City

TB-500 is the half of the BPC plus TB stack you feel slower but deeper, and the use case I keep coming back to in HCMC is the chronic Achilles flare-ups from running the District 2 riverside path along the Saigon River and the broken-tile sections through Thao Dien village. Single 5mg loading dose subcutaneous in the belly Sunday night, then 2.5mg twice weekly Wednesday and Saturday, and by the third week the heel pain that lingered for 6 months is gone. The shoulder labrum tweak I picked up at Saigon Sports Club BJJ in November responded the same way; full range of motion back by week 5 with no PT visits. I keep the reconstituted vial in the apartment fridge in An Phu, sealed with parafilm to control humidity, and use it within 14 days. The downside is the cost; verified TB-500 sourced through cold-chain importers in Vietnam runs 2.5 to 4 million VND per 5mg vial, roughly double the BPC equivalent, so most people I know running the stack reserve TB for the actual injury cycle and stay on BPC year-round. The Family Medical Practice clinic in District 2 will not prescribe or stock it; this is research-grade only.

Sourcing in Vietnam

TB-500 is not stocked at Long Châu, Pharmacity, or any retail pharmacy in Vietnam. Sourcing is through cold-chain importers with COA verification. Expect 2.5 to 4 million VND per 5mg vial; the price gap vs BPC-157 reflects synthesis difficulty. See the supplier list and COA guide before purchasing.

FAQ

Q: What is the difference between TB-500 and BPC-157?

A: BPC-157 is more locally-acting (most effective near the injury) and is particularly strong for gut healing. TB-500 is systemic, it travels throughout the body and is better for widespread inflammation, multiple injuries, or when you cannot inject near the injury. The BPC-157 + TB-500 stack combines both mechanisms.

Q: Does TB-500 really grow hair?

A: Thymosin Beta-4 has been studied for hair regrowth and activates hair follicle stem cells. Anecdotal reports from users suggest noticeable regrowth when used consistently for 3+ months. Results are modest and individual. It is not a replacement for proven hair loss treatments.

Q: Can I inject TB-500 in my stomach like other peptides?

A: Yes. Because TB-500 is systemic, you can inject it anywhere subcutaneously. The belly is the most convenient and commonly used site. Source from the community-verified supplier list and verify purity with the COA verification guide. For an overview of Vietnam's peptide regulation, see the legality guide.

Where to Get TB-500 in Vietnam

See our community-verified supplier list with COA verification and cold-chain shipping to Vietnam.

View Supply Index

Related Peptides

BPC-157 GHK-Cu ARA-290 KPV

Research & Sources

Thymosin beta 4: actin sequestration, blood vessel formation, and tissue regeneration · Goldstein AL, Hannappel E, Kleinman HK · Annals of the New York Academy of Sciences (2012) PMID: 23045981
Foundational review of thymosin beta-4 mechanisms underlying TB-500 wound healing and angiogenic effects.
Thymosin beta 4 and cardiac protection: implication in inflammation and fibrosis · Sosne G, Qiu P, Goldstein AL, Wheater M · Annals of the New York Academy of Sciences (2010) PMID: 20425002
Cardiac and anti-fibrotic effects of thymosin beta-4 supporting systemic healing claims.
Thymosin beta-4 promotes wound healing and tissue regeneration: clinical and preclinical evidence · Crockford D, Turjman N, Allan C, Angel J · Annals of the New York Academy of Sciences (2010) PMID: 20840533
Phase 2 clinical trial data supporting wound-healing claims and dosing rationale.
Thymosin beta-4: a multi-functional regenerative peptide · Sosne G, Qiu P, Christopherson PL, Wheater MK · Expert Opinion on Biological Therapy (2007) PMID: 17696818
Mechanism review covering angiogenesis, anti-inflammatory, and stem cell recruitment effects.

Important Disclaimer

Educational content only. Not medical advice. Peptides discussed on this page are not approved by Vietnam’s Ministry of Health (Bộ Y Tế) or the Drug Administration of Vietnam (DAV) for the indications described. Research peptides are not stocked at Long Châu, Pharmacity, or any retail pharmacy in Vietnam. Consult a licensed physician before any use.