DSIP Dosage Calculator: Reconstitution & Syringe Units
This DSIP dosage calculator works out the strength of your mix and the U-100 syringe units for an amount you bring, from the vial mg and the water mL. DSIP, short for delta sleep-inducing peptide, is a chain of nine amino acids that FDA calls emideltide. FDA lists no approved drug that contains it, so the amount box starts empty.
DSIP calculator: vial, water and amount
Put in the vial mg, the water you used and an amount in mg from your own source. Micrograms go in as mg: divide by 1,000, so 250 mcg is 0.25 mg. If your figure is in nmol per kg, as in the old studies, the nmol section below shows the conversion first.
DSIP vial math
The 5 mg vial and 2 mL of water are a sample to show the layout. Replace them with the figures for your own vial.
As printed on the vial label.
The full volume you added.
A figure you already have, in mg.
U-100 marks: 100 units fill 1 mL.
Enter all three numbers to see the math.
Disclaimer: this tool converts numbers. It does not choose an amount for anyone, and any dose belongs with a licensed clinician.
Peptara Labs, our supply partner, sells DSIP as a 10 mg freeze-dried vial for research use. Its product page says no purity figure is claimed until the batch certificate is out.
See DSIP at Peptara LabsWe may earn from purchases made through our links.
Sources: US FDA, briefing document on emideltide (DSIP), free base and acetate, Pharmacy Compounding Advisory Committee, 23 to 24 July 2026; MedlinePlus, U-100 syringe basics
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How does the DSIP math work?
The calculator does three sums, in this order. You can follow each one on paper.
- Vial mg divided by water mL gives the strength, in mg per mL.
- Your amount in mg divided by the strength gives the mL to draw.
- That mL times 100 gives the units, since each mL on a U-100 syringe is split into 100 unit marks.
Here are the steps for 5 mg in 2 mL, using 1 mg purely as a sample:
5 mg / 2 mL = 2.5 mg per mL
1 mg / 2.5 mg per mL = 0.4 mL
0.4 mL x 100 = 40 units
So at this strength, one unit carries 0.025 mg, which is 25 mcg. The same 1 mg from a 10 mg vial with 2 mL is half the volume: 0.2 mL, or 20 units.
FDA's 2026 review found DSIP sold as a 5 mg freeze-dried vial and as a ready liquid at 2 mg per mL in a 4 mL vial. For a ready liquid, enter 2 as the vial mg and 1 as the water mL, which gives the 2 mg per mL printed on it. For more on reading the marks, see the mL to units guide.
Sources: US FDA, briefing document on emideltide (DSIP), free base and acetate, Pharmacy Compounding Advisory Committee, 23 to 24 July 2026; MedlinePlus, U-100 syringe basics
Will DSIP fully dissolve at the strength you mix?
That is a fair question for this peptide. FDA's 2026 review says the free base of DSIP is reported to have limited water solubility. It adds that it is unclear how even a 1 mg per mL injection could be made from it. Each mix in this table is stronger than that:
| Mix | Strength | Compared with 1 mg per mL |
|---|---|---|
| Ready liquid sold at 2 mg per mL | 2 mg per mL | 2 times |
| 5 mg vial with 2 mL of water | 2.5 mg per mL | 2.5 times |
| 10 mg vial with 3 mL of water | 3.33 mg per mL | 3.3 times |
| 10 mg vial with 2 mL of water | 5 mg per mL | 5 times |
| 10 mg vial with 1 mL of water | 10 mg per mL | 10 times |
Why it matters for the math: the calculator assumes every mg in the vial ended up in the liquid. If grains or a haze are still there after gentle swirling, part of the peptide is not dissolved, and the real strength is lower than the screen says.
The form on the label is a second unknown. FDA treats the free base, at 848.8 g per mol, and DSIP acetate, at 848.8 plus 60 for each acetate, as different substances. With one acetate the weight is 908.8, so a 10 mg vial of that salt holds about 9.34 mg of DSIP itself. None of the websites FDA searched said which form they sell.
Sources: US FDA, briefing document on emideltide (DSIP), free base and acetate, Pharmacy Compounding Advisory Committee, 23 to 24 July 2026; PubChem, Delta Sleep-Inducing Peptide, compound 68816
How do nmol per kg study doses turn into mcg?
The human DSIP studies set their doses in nanomoles (nmol) per kg of body weight, not in mg. A nanomole counts molecules, so you need the weight of one mole to change it into a mass. For DSIP that weight is 848.8 g.
The rule, with the most common study figure as the example:
mcg = nmol x 848.8 / 1,000
25 nmol x 848.8 / 1,000 = 21.2 mcg
So 25 nmol per kg is 21.2 mcg per kg, close to the 21.3 to 21.4 mcg per kg FDA's review gives. A slipped decimal point is easy here, and it makes an answer ten times off. The table runs the three study figures for a 70 kg adult:
| Study dose | As mcg per kg | For a 70 kg adult |
|---|---|---|
| 25 nmol per kg | 21.2 mcg per kg | 1,485 mcg, about 1.5 mg |
| 30 nmol per kg | 25.5 mcg per kg | 1,782 mcg, about 1.8 mg |
| 35 nmol per kg | 29.7 mcg per kg | 2,080 mcg, about 2.1 mg |
Disclaimer: these turn study doses into a familiar unit. Each was given into a vein, under supervision, to people in a study. They are not a dose for you, and the calculator above does not use them.
Sources: PubChem, Delta Sleep-Inducing Peptide, compound 68816; US FDA, briefing document on emideltide (DSIP), free base and acetate, Pharmacy Compounding Advisory Committee, 23 to 24 July 2026; Schneider-Helmert and Schoenenberger, Experientia 1981, PMID 7028502: 6 adults with chronic insomnia
What doses did the DSIP studies use?
FDA's 2026 review gathered every human DSIP study it could find. Across them, 209 people got 25 to 150 nmol per kg into a vein for 1 to 15 days. The main sleep and withdrawal studies, as their abstracts and FDA's summaries give them:
| Amount | Schedule | Route | Who | Study |
|---|---|---|---|---|
| 25 nmol per kg | One shot on each test night, pushed over 4 minutes just before bed | Into a vein | People: 6 middle-aged adults with chronic insomnia | Schneider-Helmert and Schoenenberger, 1981 |
| 25 nmol per kg | 4 nights of DSIP or placebo in random order, done twice with a 4 day break | Into a vein | People: 6 adults with severe chronic insomnia | Monti and colleagues, 1987 |
| 30 nmol per kg | 6 doses spread over one week, per the abstract (FDA counts 5 evenings) | Into a vein | People: 18 adults with chronic insomnia, aged 29 to 83 | Schneider-Helmert, 1986 |
| 30 nmol per kg | 7 nights in a row | Into a vein | People: 14 middle-aged adults with chronic insomnia | Schneider-Helmert, 1987 |
| 25 nmol per kg | In the afternoon before each of 3 nights; half the group got a sugar solution instead | Into a vein | People: 16 adults with chronic insomnia | Bes and colleagues, 1992 |
| 25 nmol per kg, up to 6 shots a day for up to 6 days | On request, or every 6 to 8 hours, during withdrawal | Into a vein | People: 107 hospital patients going through alcohol or opiate withdrawal | Dick and colleagues, 1984 |
| 35 nmol per kg | Fixed plan over 7 days, from up to 6 shots a day down to 2 | Into a vein | People: 7 adults with opioid dependence | Backmund and colleagues, 1998 |
Disclaimer: every figure above is a research dose given into a vein in a study setting. None is a dose for you, DSIP has no approved dose, and a licensed clinician makes any dose decision.
The results do not agree. Studies led by Schneider-Helmert reported better sleep. Two double-blind studies by other teams found little: Monti and colleagues saw changes of little clinical significance, and Bes and colleagues judged the effect too weak to be of major benefit. FDA's review calls the insomnia evidence inconclusive and at best preliminary.
FDA also found no human study that injected DSIP under the skin, the route that the withdrawn compounding nominations had proposed. The peptide itself was named in a 1977 rabbit study, where only the full nine amino acid chain raised deep-sleep brain waves.
Sources: US FDA, briefing document on emideltide (DSIP), free base and acetate, Pharmacy Compounding Advisory Committee, 23 to 24 July 2026; Schneider-Helmert and Schoenenberger, Experientia 1981, PMID 7028502: 6 adults with chronic insomnia; Monti and colleagues, International Journal of Clinical Pharmacology Research 1987, PMID 3583493; Schneider-Helmert, European Neurology 1986, PMID 3792404: 18 adults aged 29 to 83; Schneider-Helmert, European Neurology 1987, PMID 3622582: 14 adults over 7 nights; Bes and colleagues, Neuropsychobiology 1992, PMID 1299794: 16 adults, double-blind; Dick and colleagues, European Neurology 1984, PMID 6548969: 107 patients in withdrawal; Backmund and colleagues, Journal of Clinical Psychopharmacology 1998, PMID 9617990: 7 adults in opioid detox; Schoenenberger and Monnier, PNAS 1977, PMID 265572: the rabbit study that named DSIP
What do FDA and the studies say about safety?
FDA places emideltide on its list of substances that may carry significant risks in compounding. It warns that some routes could set off an immune reaction, and says it lacks the information to know whether DSIP would cause harm by the route that was proposed.
In the vein studies of insomnia, DSIP was well tolerated, with no significant side effects reported. The large withdrawal study is the exception. Nine of its 107 patients had brief side effects such as sweating, headache, nausea and dizziness. Three had serious ones: two had low blood pressure at the start of their first shot, and a third had repeated spells of discomfort, sweating and nausea lasting 15 minutes. One of those three got a second shot and then had what FDA's summary calls progressive hypotension, blood pressure that kept falling. FDA found no DSIP reports in its adverse event database up to 3 March 2024.
DSIP also leaves the blood fast: FDA gives its plasma half-life as about 8 minutes. For more on how it compares with other sleep peptides, see our guide to peptides studied for sleep and the DSIP profile.
Sources: FDA compounding risk list, emideltide row; US FDA, briefing document on emideltide (DSIP), free base and acetate, Pharmacy Compounding Advisory Committee, 23 to 24 July 2026; Dick and colleagues, European Neurology 1984, PMID 6548969: 107 patients in withdrawal
How long does DSIP keep?
FDA's 2026 review quotes reported figures for the raw powder. The free base keeps about three years at -20°C and about two years under 4°C, and the freeze-dried powder keeps about three weeks at room temperature. A solution of the acetate keeps more than a month at -20°C, and freezing and thawing it again and again should be avoided.
None of those figures is for a vial mixed with bac water and kept in a fridge. Our FAQ on refrigerating bac water deals with the water. Its FDA label calls it sterile water for repeated withdrawals, kept clean by 0.9% or 1.1% benzyl alcohol.
Sources: US FDA, briefing document on emideltide (DSIP), free base and acetate, Pharmacy Compounding Advisory Committee, 23 to 24 July 2026; DailyMed bacteriostatic water label, set 87d6e9dc
How to mix a DSIP vial
These steps stop at the vial: they turn the powder into a liquid whose strength the calculator can work out. They do not set any amount, and the page has no steps for giving a shot, which is a matter for a licensed clinician.
- Note the vial size. Read the mg on the DSIP label and keep it handy. If the label names the free base or an acetate, note that as well.
- Clean both caps. Rub the stopper of the DSIP vial and of the water vial with an alcohol wipe, then wait until they are dry.
- Draw your water. Take up the bac water volume you settled on in a fresh syringe, and remember the mL for the calculator.
- Add the water slowly. Put the needle through the stopper and let the water slide down the glass rather than spraying onto the dry peptide.
- Swirl and check. Swirl gently until the liquid is fully clear. Grains or haze that stay mean some powder has not dissolved.
- Label the mix. Mark the vial with the date and the mg per mL, so every later reading starts from the same strength.
Working out a pineal peptide too? Our epitalon vial calculator handles large epitalon vials and its acetate form.
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Common questions
How many units is 1 mg of DSIP?+
With 2 mL added to a 5 mg vial, 1 mg comes to 0.4 mL, read as 40 units. Add the same 2 mL to a 10 mg vial and it halves to 0.2 mL, or 20 units.
How much bac water should a 5 mg DSIP vial get?+
No study or label gives a volume. 2 mL makes 2.5 mg per mL. FDA notes that the free base is reported to dissolve poorly in water, so check that the liquid turns fully clear before you trust the math.
How do I turn nmol of DSIP into mcg?+
Multiply the nmol by 0.8488. DSIP weighs 848.8 g per mol, so 1 nmol is about 0.85 mcg and 10 nmol is about 8.5 mcg. Mixing up the decimal place here gives an answer ten times too small or too large.
Is DSIP the same as melatonin?+
No. DSIP is a chain of nine amino acids that weighs 848.8 g per mol. Melatonin is a far smaller molecule, at 232.28 g per mol. Both show up in sleep research, but they are different substances.
Does DSIP lower cortisol?+
In a 1985 rat study, DSIP given into a vein shrank the rise in corticosterone, the rat stress hormone, after a CRF challenge. That was an animal result, and it does not show the same thing happens in people.
Does this calculator pick a DSIP dose?+
No. Its job ends at the arithmetic: strength, volume and units for figures you type. How much DSIP to use, or whether to use it at all, is outside what a calculator can say.
Sources: US FDA, briefing document on emideltide (DSIP), free base and acetate, Pharmacy Compounding Advisory Committee, 23 to 24 July 2026; PubChem, Delta Sleep-Inducing Peptide, compound 68816; PubChem, Melatonin, compound 896; Graf and colleagues, Neuroendocrinology 1985, PMID 2995861: corticosterone in rats
More on DSIP
Peptides Vietnam offers this tool for unit and strength math on the figures you supply. It gives no medical advice and never sets an amount for anyone. No FDA-approved drug contains DSIP.