CJC-1295 (with DAC)
Long-acting GHRH analogue with Drug Affinity Complex — once or twice weekly GH pulse for sustained elevation.
Category
Growth Hormone
Frequency
1–2x weekly
Research
Phase 2 Clinical TrialsWhat is CJC-1295 (with DAC)?
CJC-1295 with DAC (Drug Affinity Complex) is a modified form of Growth Hormone Releasing Hormone (GHRH) that includes a Drug Affinity Complex — a chemical modification that allows it to bind to albumin in the blood, dramatically extending its half-life from minutes to 6–8 days.
This long half-life enables once or twice weekly dosing, creating what is known as a 'GH bleed' — a sustained elevation in growth hormone levels rather than sharp pulsatile spikes. This is fundamentally different from CJC-1295 without DAC, which produces short, natural-pattern GH pulses.
The sustained GH elevation from CJC-1295 with DAC is preferred by users seeking body composition changes (more muscle, less fat) over the long-term, as it maintains growth factor levels more consistently. However, some argue that constant GH elevation is less physiological than pulsatile release.
How It Works
GHRH Mimicry: CJC-1295 (with DAC) binds to the GHRH receptor in the pituitary gland, stimulating the release of growth hormone.
Albumin Binding: The DAC modification causes the peptide to bind to albumin (the most abundant blood plasma protein), protecting it from enzymatic degradation and extending its half-life to 6–8 days.
IGF-1 Elevation: Elevated GH stimulates the liver to produce IGF-1 (Insulin-like Growth Factor 1), which is responsible for many of GH's anabolic and regenerative effects in muscle and connective tissue.
Benefits
- Once or twice weekly dosing convenience
- Sustained GH and IGF-1 elevation
- Improved lean muscle mass and body composition
- Enhanced fat oxidation, especially visceral fat
- Improved recovery and connective tissue health
- Better sleep architecture
- Anti-aging and skin quality improvements
Dosing Protocol
| Phase | Dose | Frequency | Duration |
|---|---|---|---|
| Standard | 1–2mg | Once per week | 8–12 weeks |
| Stacked (with Ipa) | 1mg CJC + 300mcg Ipa | 2–3x per week | 12 weeks |
Always start at the lowest effective dose and titrate up gradually.
Side Effects
Common
- ⚠Water retention (can be significant)
- ⚠Tingling in hands and feet
- ⚠Fatigue in first 1–2 weeks
- ⚠Mild headaches
- ⚠Increased hunger
Rare
- •Hypoglycemia (if injected near meal)
- •Elevated cortisol in sensitive individuals
- •Carpal tunnel syndrome with long-term high dose use
Who Should NOT Use CJC-1295 (with DAC)
- ✕Active cancer
- ✕Diabetic retinopathy
- ✕Pregnancy or breastfeeding
- ✕Poorly controlled diabetes
What to Expect
Water retention noticeable. Sleep may improve. Mild fatigue as GH levels rise.
Body composition begins shifting. Recovery faster. Skin quality improving.
Clear anabolic effects. Lean mass increasing. Fat (especially visceral) decreasing.
Full benefits established. Most cycle 12 weeks on, 4–8 weeks off.
FAQ
Q: CJC-1295 with DAC or without DAC — which should I choose?
A: With DAC gives a GH bleed (sustained elevation, dosed weekly). Without DAC gives pulsatile release (more natural, dosed daily). With DAC is more convenient but the constant elevation may cause more water retention. For body composition goals, with DAC is often preferred. For sleep and recovery, without DAC + Ipamorelin before bed is often better.
Q: Should I combine CJC-1295 (with DAC) with Ipamorelin?
A: Yes, but note that with DAC the Ipamorelin is less critical than with the no-DAC version because CJC-DAC already provides sustained stimulation. Many users do add Ipamorelin doses 2–3x weekly for additional GH pulses.
Where to Get CJC-1295 (with DAC) in Vietnam
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