BPC-157 Reconstitution Calculator
Turn a target dose you already have into the exact injection volume and insulin syringe units for your vial. The math only. It never picks a dose for you.
Most people who search for a BPC-157 calculator want a tool that tells them what to inject. This is not that. What number to run, and whether to run it at all, is a decision for a licensed prescriber who knows your history. This tool handles the part that is pure arithmetic: once you already have a target dose from your own protocol or supplier, it converts that dose into a concentration, an injection volume in millilitres, and the units to draw on an insulin syringe. Nothing more.
Enter your own numbers
The target dose starts at zero, because this page never suggests a figure for you. Drag it to whatever your protocol source specifies and the math updates as you move it.
Target dose from your protocol or supplier. This slider starts at zero and nothing calculates until you move it, because no number here is a recommended, standard, or safe dose. Drag it to your own figure and the results appear below.
What the evidence and the community report
These are amounts recorded in published studies and label documents, not recommendations. The Who column says whether a figure came from people or from animals, and the Ref column points to the full citation in Sources below.
A. Approved label doses
None. No regulator has approved BPC-157, no label sets a figure for it, and a DailyMed search returns zero records.
B. Amounts administered in published studies
Not one of these studies used subcutaneous injection, the route this calculator implies, so none of these figures is a subcutaneous figure.
| Amount | Schedule | Route | Who | Ref |
|---|---|---|---|---|
| 10 microgram/kg/day | once daily | intraperitoneal | rat, n=32 | [7] |
| 20 microgram/kg | single administration at the 45th minute of ischemia | intraperitoneal | rat, n=24 | [8] |
| 0.25, 0.5, 1 and 2 mg/kg, or placebo | single dose, one week washout, then seven further doses once daily for seven days | rectal enema | human, n=32 | [9] |
| 80 mg | once daily for two weeks | rectal enema | human, n=53 | [10] |
| 2 to 4 mg | 1 to 2 doses | intra-articular injection | human, n=17 | [11] |
| 1 mg placed in each of 10 spots, a total of 10 mg | single procedure | intravesical injection | human, n=12 | [12] |
| 10 mg on day 1, then 20 mg on day 2 | infused over 1 hour each day | IV infusion | human, n=2 | [13] |
| planned as 1 mg, 3 mg or 6 mg in phase 1a, then 3 mg in phase 1b | single dose in phase 1a, then every 8 hours for two weeks in phase 1b | oral tablet | human, n=42 estimated | [14] |
C. Community reported practice
None. The only figures found trace to a vendor selling the compound, so this page does not carry them.
Disclaimer: no figure here is a recommendation, per kilogram figures are never converted for you, and this is education, not medical advice.
Two worked math examples
Both examples use 250 mcg because it is a round number that keeps the arithmetic easy to follow, not because this page recommends it. It is not a suggested dose. Use the figure your own protocol source specifies.
Example A: 5 mg vial with 2 mL
Math illustration, not a dose to take. The concentration is 5 / 2 = 2.5 mg/mL, or 2500 mcg/mL. A 250 mcg target gives 250 / 2500 = 0.1 mL, which is 10 units on a U-100 syringe. The vial contains 5000 / 250 = 20 illustrative draws.
Example B: 10 mg vial with 3 mL
Math illustration, not a dose to take. The concentration is 10 / 3 = 3.33 mg/mL, or about 3333 mcg/mL. A 250 mcg target gives 0.075 mL, which is 7.5 units on a U-100 syringe. The vial contains 10000 / 250 = 40 illustrative draws.
The target number stays the same in both examples, while the vial amount and water volume change the concentration and syringe reading. Enter your own numbers above to run the same calculation.
What this calculator does, and what it will not do
A reconstitution calculator answers a mechanical question. You have a vial of freeze dried peptide and add a known volume of water. That fixes the concentration. From there, any target number you enter has one matching draw volume, and the calculator finds it. There is no judgment in that step, only division.
What it will not do is choose the dose. A tool that reads your weight or goals and hands back "inject this much" is giving medical advice, and this calculator does not do that. The target dose is something you bring to the calculator, not something it gives you. If you do not have a number from a licensed prescriber or a protocol source you trust, no calculation on this page can supply one.
How to reconstitute a BPC-157 vial
If your vial contains lyophilized powder, reconstitution means adding the water volume you entered above and letting the powder dissolve. These are general vial-handling steps, not instructions for choosing or administering a dose.
- Wipe both rubber stoppers, the peptide vial and the water vial, with an alcohol swab and let them dry.
- Draw the water volume you entered in the calculator into a syringe.
- Insert the needle at a slight angle so the water runs down the inside wall of the vial rather than directly onto the powder.
- Inject the water slowly. Do not shake the vial. Swirl gently until the solution is clear.
- Label the vial with the date and the calculated concentration in mg/mL.
- Follow the supplier's written storage and handling instructions.
Water choice and storage sit outside the calculator's arithmetic. For the difference between the two common water types, see bacteriostatic water vs sterile water. For a general mixing walkthrough, see how to use peptides.
Picking the BAC water volume
The amount of water you add does not change how much peptide is in the vial. It changes the concentration and therefore the liquid volume for the target number you enter. A 5 mg vial reconstituted with 1 mL is twice as concentrated as the same vial with 2 mL, so the draw is half the volume for the same target. More water spreads the syringe marks out, while less water concentrates the draw. The calculator recomputes instantly so you can compare volumes and use the written instructions that came with your vial.
Reading the insulin syringe
The calculator uses the U-100 conversion:
1 unit = 0.01 mL
100 units = 1 mL = full 1 mL barrel
A result of 0.5 mL is 50 units, and a result of 0.25 mL is 25 units. The calculator shows both formats so you can match the volume to a U-100 syringe. It also checks the result against the selected 0.3 mL, 0.5 mL, or 1.0 mL barrel capacity.
Why the calculator does not choose a dose
The published record below consists of animal studies, cell-culture work, and reviews. The 2012 review says BPC-157, identified there as PL 14736, had only been tested in clinical phase II, but it does not provide a published human dose-finding result (PMID: 22300085). Those papers do not give a calculator a basis for selecting a target number.
The sources are included to explain that boundary, not to turn the calculator into a compound explainer. For information about the compound itself, read the BPC-157 compound profile.
Sources
1. Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol. 2009 Dec;60 Suppl 7:191-6. PMID: 20388964.
2. Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011 Mar;110(3):774-80. PMID: 21030672. DOI: 10.1152/japplphysiol.00945.2010.
3. Cerovecki T, Bojanic I, Brcic L, Radic B, Vukoja I, Seiwerth S, et al. Pentadecapeptide BPC 157 (PL 14736) improves ligament healing in the rat. J Orthop Res. 2010 Sep;28(9):1155-61. PMID: 20225319. DOI: 10.1002/jor.21107.
4. Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, et al. Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Drug Des Devel Ther. 2015;9:2485-99. PMID: 25995620. DOI: 10.2147/DDDT.S82030.
5. Sikiric P, Seiwerth S, Rucman R, Kolenc D, Vuletic LB, Drmic D, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865. PMID: 27138887. DOI: 10.2174/1570159x13666160502153022.
6. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, et al. Focus on ulcerative colitis: stable gastric pentadecapeptide BPC 157. Curr Med Chem. 2012;19(1):126-32. PMID: 22300085. DOI: 10.2174/092986712803414015.
7. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. Jt Dis Relat Surg, 2026. PMID: 42542926. Rat, Sprague-Dawley, Achilles tendon transection and repair model. n = 32 rats total, 8 per group. Route: intraperitoneal. Rodent per kilogram figure, stated per kilogram.
8. Protective effects of BPC 157 in rats with experimentally induced lower extremity ischemia-reperfusion injury. Sci Rep, 2026. PMID: 42204242. Rat, Wistar albino, lower extremity ischemia reperfusion injury. n = 24 rats, 6 per group. Route: intraperitoneal. Rodent per kilogram figure, stated per kilogram.
9. FDA Briefing Document, Pharmacy Compounding Advisory Committee, July 23 to 24 2026, BPC-157 related bulk drug substances, Appendix 1 Previous Human Experience with BPC-157, Veljaca et al. 2002 and 2003 (meeting abstracts). https://www.fda.gov/media/193343/download. Human, healthy subjects. n = 32 randomized, 24 received BPC-157, 6 per dose group plus 2 placebo. Route: rectal enema. Human per kilogram figure, recorded unconverted. Read verbatim from the FDA document. The underlying meeting abstracts are not indexed on PubMed and could not be retrieved, so this is confirmed as what FDA reports, not against the original report.
10. FDA Briefing Document, Pharmacy Compounding Advisory Committee, July 23 to 24 2026, BPC-157 related bulk drug substances, Appendix 1 Previous Human Experience with BPC-157, Ruenzi et al. 2005 (meeting abstract), titled as a phase II study of PL 14736 enema. https://www.fda.gov/media/193343/download. Human, subjects with mild to moderate ulcerative colitis. n = 53 randomized, 46 completed. Route: rectal enema. Run under the development code PL 14736. Read verbatim from the FDA document; the underlying meeting abstract could not be retrieved. FDA states in the same document that it found a lack of evidence to support effectiveness for ulcerative colitis and that the substance is not well characterized.
11. FDA Briefing Document, Pharmacy Compounding Advisory Committee, July 23 to 24 2026, Appendix 1, Lee E and Padgett B 2021, Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain. PMID: 34324435 and https://www.fda.gov/media/193343/download. Human, subjects with knee pain. n = 17 identified, 16 contacted by investigators. Route: intra-articular injection. Retrospective chart review at a single clinic. Given alone or combined with thymosin beta-4. The figure is verbatim from the FDA appendix; the PubMed abstract does not itself state a milligram amount.
12. FDA Briefing Document, Pharmacy Compounding Advisory Committee, July 23 to 24 2026, Appendix 1, Lee et al. 2024, single arm study at UroGyn Specialists of Florida. PMID: 39325560 and https://www.fda.gov/media/193343/download. Human, women with moderate to severe interstitial cystitis. n = 12 women. Route: intravesical injection into the uroepithelium of the bladder wall, performed as a single procedure by a clinician. FDA footnotes that the material was compounded by a 503A compounding pharmacy that did not wish to disclose its name.
13. Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study. Altern Ther Health Med, 2025 (Lee and Burgess). PMID: 40131143. Human, 2 adults described as healthy. n = 2, a 58 year old male and a 68 year old female. Route: intravenous infusion, each dose in 250 cc normal saline. A pilot safety report at a private clinic, not an efficacy or dose finding study. Both subjects had received intravenous BPC-157 before the trial.
14. NCT02637284 as described in the FDA Briefing Document, Pharmacy Compounding Advisory Committee, July 23 to 24 2026, Appendix 1. https://www.fda.gov/media/193343/download. Human, healthy subjects, Mexico. n = estimated enrollment 42. Route: oral tablet. Planned amounts only. The registry record carries no amount in its own fields, these figures come from the FDA description of the protocol, and FDA states there are no results posted and it could not find an associated published study. It is unclear whether these amounts were ever administered.
Frequently asked questions
Is there a standard BPC-157 dose I can put in this calculator?
No published source listed on this page supplies a human dose-finding result. The target dose starts at zero for that reason, because there is no number this page could honestly put there for you. You drag the slider to the figure your own prescriber or a protocol you trust specifies, and nothing calculates until you do. The tool does the math on that number and nothing else.
How do I use this calculator for the dose my own protocol specifies?
That is exactly what it is built for. The target dose starts at zero and waits for your number. Drag the slider to whatever figure your own protocol or supplier specifies, in mcg or mg, and the calculator works out the injection volume, the insulin syringe units, and how many doses your vial holds. It never judges the number you set. It only does the arithmetic on it.
How much BAC water do I add to a 5 mg BPC-157 vial?
There is no single answer from the calculator because water volume is a readability choice, not a potency choice. A 5 mg vial in 2 mL of water gives a concentration of 2.5 mg/mL. The same vial in 1 mL gives 5 mg/mL, so whatever dose you enter draws half the volume at the higher concentration. More water spreads the marks out on the syringe, less water concentrates the draw, and neither changes how much peptide is in the vial. For the same arithmetic without a compound preset, use the general peptide reconstitution calculator.
Why does this calculator not choose a target dose?
A reconstitution calculator can divide the peptide in a vial by the water added, but it cannot turn animal studies, cell-culture work, or a protocol from somewhere else into medical advice. The cited record does not provide a published human dose-finding result. You bring the target number, and the calculator handles only the concentration and draw math.
Why does changing BAC water change the syringe reading?
The amount of peptide in the vial stays fixed. Adding more water lowers the concentration, so the same target dose needs a larger draw volume. Adding less water raises the concentration, so the same target dose needs a smaller draw volume. The calculator updates both the millilitres and U-100 syringe units when you move the water slider.
How do I read insulin syringe units?
On a U-100 insulin syringe, 1 unit equals 0.01 mL and 100 units equals 1 mL. The calculator multiplies the injection volume in millilitres by 100 and shows the result as syringe units. Check that result against the markings and capacity of the syringe you selected.
Is this calculator medical advice?
No. It is harm reduction education. It performs reconstitution arithmetic on numbers you supply. It does not diagnose, does not prescribe, and does not tell you what dose to take. Dose and schedule are a prescriber decision. Always cross-check with your protocol source, supplier instructions, and where possible a qualified clinician.
This is harm reduction education, not medical advice
This calculator is for educational use. It converts a dose you already have into a volume and syringe reading. It does not choose a dose. Peptide protocols vary between individuals and compounds. Always cross-check with your protocol source, supplier instructions, and where possible a qualified clinician.