GLP-1 Agonists
Weight Loss Peptides
GLP-1 agonists are the most effective weight loss compounds ever developed. Here's everything you need to know.
How GLP-1 Peptides Work
Appetite Suppression
Signal the brain to reduce hunger and increase satiety, naturally reducing caloric intake.
Insulin Response
Enhance insulin secretion in response to food, improving blood sugar management.
Slower Gastric Emptying
Food stays in the stomach longer, extending fullness and reducing cravings.
Comparison Table
| Peptide | Receptors | Avg Loss | Frequency | Status |
|---|---|---|---|---|
| ★Retatrutide | GLP-1, GIP, Glucagon (3) | 28.7% | Weekly | Phase 3 |
| Tirzepatide | GLP-1, GIP (2) | 22.5% | Weekly | FDA Approved |
| Semaglutide | GLP-1 (1) | 15% | Weekly | FDA Approved |
| Cagrilintide | Amylin | 10%+ | Weekly | Phase 3 |
| Mazdutide | GLP-1, Glucagon (2) | 18%+ | Weekly | Phase 3 |
Which Should You Choose?
Maximum weight loss
RetatrutideMost studied / safest data
Tirzepatide or SemaglutideBudget option
SemaglutideNew to GLP-1s
Start with Semaglutide or Tirzepatide